Observational studies have shown that mesoscale variations in sea surface temperature may induce mesoscale variations in wind. In eastern subtropical upwelling regions such as the California coast, this mechanism could be of great importance for the mean state and variability of the climate system. In coastal regions orography also creates mesoscale variations in wind, and the orographic effect may extend more than 100 km offshore. The respective roles of SST/wind links and coastal orography in shaping mesoscale wind variations in nearshore regions is not clear. We address this question in the context of the California Upwelling System, using a high-resolution regional numerical modeling system coupling the WRF atmospheric model to the ROMS oceanic model, as well as additional uncoupled experiments to quantify and separate the effects of SST/wind links and coastal orography on mesoscale wind variations. After taking into account potential biases in the representation of the strength of SST/wind links by the model, our results suggest that the magnitude of mesoscale wind variations arising from the orographic effects is roughly twice that of wind variations associated with mesoscale SST anomalies. This indicates that even in this region where coastal orography is complex and leaves a strong imprint on coastal winds, the role of SST/winds links in shaping coastal circulation and climate cannot be neglected.